Acute and Chronic Cough (Lung Biology in Health and Disease, by Anthony E. Redington, Alyn H. Morice

By Anthony E. Redington, Alyn H. Morice

A accomplished evaluate of the clinical and scientific features of acute and protracted cough, this reference makes a speciality of contemporary advancements in our realizing of the molecular biology of putative cough receptors, the neural mechanisms concerned with the afferent and efferent limbs, the critical processing of the cough reflex, and peptides and different elements that could mediate or modulate the cough reflex. With chapters wriitenby said experts within the box, this instruction manual covers present and power healing brokers, a number of methodologies to degree cough reflex sensitivity, and medical ways for the review of power cough in adults and youngsters.

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67. Lee LY, Kwong K, Lin YS, Gu Q. Hypersensitivity of bronchopulmonary C-fibers induced by airway mucosal inflammation: cellular mechanisms. Pulm Pharmacol Ther 2002; 15:199–204. 68. Hu HJ, Bhave G, Gereau RW 4th. Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic 20 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. 81. 82. 83. Hwang glutamate receptor 5: potential mechanism for thermal hyperalgesia. J Neurosci 2002; 22:7444–7452. Szallasi A, Blumberg PM.

Of the various kinds of ion channel expressed in sensory afferents, TRPV1 is probably the best known due to its physiologic importance in sensory mechanisms. The biophysical characteristics of the cloned TRPV1 channel are almost identical to those of the native capsaicin-activated channel (Figs. 2 and 3). TRPV1 shows a selective expression profile in the peripheral nervous system (16,18,25). It is believed to be the transducer of capsaicin-mediated responses in sensory nerves and is also activated by noxious high temperature or acidic pH (25), so that it is now accepted as a sensor of multiple harmful environmental and inflammatory conditions (26).

Cough and Gender . . . . . . . . . . . . . . 373 Masaki Fujimura Gender Distribution in Causes of Chronic Cough . . 373 Gender Difference in Cough Reflex Sensitivity . . 377 Possible Mechanism of Female Preponderance in Chronic Cough . . 380 References . . 383 22. Impact of Cough on Health Status . . . . . . . . Surinder S. Birring and Ian D. Pavord Introduction . . 389 Adverse Impact of Cough on Health Status . . 390 Assessment of Health Status . . 390 Health Status in Chronic Cough .

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