Anesthesia [2 vols] by R. Miller

By R. Miller

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Sigmund Freud and Karl Koller Sigmund Freud and Karl Koller, an intern in the Department of Ophthalmology at the Allgemeinen Krankenhaus in Vienna, used a dynamometer to study the effect of coca on muscle strength. Both researchers noticed the numbing effect on the tongue as they swallowed the experimental drug. Koller had a burning desire to anesthetize the cornea and conjunctiva for ophthalmologic operations and had already tried morphine and chloral bromide. In Freud's absence, he and Joseph Gartner dissolved a trace of the white powder in distilled water and instilled the solution into the conjunctival sac of a frog.

The stature of the Society was enhanced by incorporation of the Wood Library- Museum of Anesthesiology in 1950; to accommodate its multiple activities, a society headquarters was erected in Park Ridge, Illinois, in 1962, with an addition 2 years later to house the Library-Museum. The American Society of Anesthesiologists has dedicated itself to the following goals and endeavors: standards for equipment and patient care, education, repeated self-analysis via survey to crystallize the state and objectives of the Society, issues of manpower, affiliation with the World Federation of Societies of Anesthesiologists, and consideration of problems common to all kinds of medical practice.

The pharmacokinetics of intravenously administered drugs is determined by distribution volumes and the processes of clearance. We first discuss the physiologic basis of pharmacokinetics, and then pharmacokinetic models that relate dose to plasma or tissue concentration. 16 Fundamental Pharmacokinetic Concepts Volume of Distribution The distribution of a drug throughout the plasma and tissues can be viewed as a process of dilution from the highly concentrated solution in the syringe to the dilute concentration in the plasma.

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